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KMID : 0377519810060020181
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 2 p.181 ~ p.187
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Diurnal Changes in Urinary Excretion of Mercury and among Healthy Male Adults
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Huh Heuck
Chung Kyou-Chull
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Abstract
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The purpose of this study was to clarify whether the diurnal variation of urinary volume, specific gravity of urine, and creatinine and mercury excretion in urine exist among healthy male adults. The results obtained were as follows: 1. Hourly urinary volume at night was considered to be below 60%, of that during the day time. The urinary volume voided at 19:00 hours showed the maximal value. 2. The volume of urine seemed to be inversely correlated with the specific gravity of urine, but the differences in specific gravity of urine by voiding time were not confirmed. 3. Diurnal changes in urinary creatinine was conspicuously noted showing the least value at 13:00 hours and the highest values at 6:00 and 23:00 hours. It was considered that creatinine was excreted more at night. 4. Mercury excretion in urine, when corrected with volume and/or specific gravity of urine showed the highest value at 60:00 and 13:00 hours. 5. Mercury excretion, when corrected with a gram of creatinine excreted in a liter of urine showed the highest value of 11.65±5.97(In 2.46±ln 1.78) ㎍Hg/g creatinine/liter of urine during a 24-hour period. It can be concluded that the urine samples should be taken at 110:00 hours as far as possible if one wants to evaluate the body burden of mercury with high sensitivity using a spot sampled urine in practice. Furthermore, it is desirable that the amount of mercury should be expressed in terms of a gram of creatinine excretion in a liter of urine, and logarithmic transformation of the actual value is necessary if a statistical comparison is to be done.
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